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Functional normalization of 450k methylation array data improves replication in large cancer studies

We propose an extension to quantile normalization that removes unwanted technical variation using control probes. We adapt our algorithm, functional normalization, to the Illumina 450k methylation array and address the open problem of normalizing methylation data with global epigenetic changes, such...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Fortin, Jean-Philippe, Labbe, Aurélie, Lemire, Mathieu, Zanke, Brent W, Hudson, Thomas J, Fertig, Elana J, Greenwood, Celia MT, Hansen, Kasper D
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283580/
https://ncbi.nlm.nih.gov/pubmed/25599564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0503-2
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