USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin

Mutations in the Park2 gene, encoding the E3 ubiquitin-ligase parkin, are responsible for a familial form of Parkinson's disease (PD). Parkin-mediated ubiquitination is critical for the efficient elimination of depolarized dysfunctional mitochondria by autophagy (mitophagy). As damaged mitochon...

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Pubblicato in:EMBO J
Autori principali: Durcan, Thomas M, Tang, Matthew Y, Pérusse, Joëlle R, Dashti, Eman A, Aguileta, Miguel A, McLelland, Gian-Luca, Gros, Priti, Shaler, Thomas A, Faubert, Denis, Coulombe, Benoit, Fon, Edward A
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2014
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283406/
https://ncbi.nlm.nih.gov/pubmed/25216678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489729
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