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Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway
The PD-1 receptor and ligands PD-L1 and PD-L2, members of the CD28 and B7 families, play critical roles in T cell coinhibition and exhaustion. Overexpression of PD-L1 and PD-1 on tumor cells and tumor-infiltrating lymphocytes, respectively, correlates with poor disease outcome in some human cancers....
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| Veröffentlicht in: | Trends Mol Med |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4282825/ https://ncbi.nlm.nih.gov/pubmed/25440090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmed.2014.10.009 |
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