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Kinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses
BACKGROUND: Host SAM domain and HD domain-containing protein 1 (SAMHD1) suppresses reverse transcription kinetics of HIV-1 in nondividing cells such as macrophages by hydrolyzing and nearly depleting cellular dNTPs, which are the substrates of viral reverse transcriptase (RT). However, unlike HIV-1,...
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| Publié dans: | Retrovirology |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4282736/ https://ncbi.nlm.nih.gov/pubmed/25524560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-014-0111-y |
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