Enhanced enzyme kinetics of reverse transcriptase variants cloned from animals infected with SIVmac239 lacking viral protein X

HIV Type 1 (HIV-1) and simian immunodeficiency virus (SIV) display differential replication kinetics in macrophages. This is because high expression levels of the active host deoxynucleotide triphosphohydrolase sterile α motif domain and histidine-aspartate domain–containing protein 1 (SAMHD1) deple...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Coggins, Si'Ana A., Kim, Dong-Hyun, Schinazi, Raymond F., Desrosier, Ronald C., Kim, Baek
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863885/
https://ncbi.nlm.nih.gov/pubmed/33008888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015273
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