Genetic Deletion of Rnd3/RhoE Results in Mouse Heart Calcium Leakage Through Upregulation of Protein Kinase A Signaling

RATIONALE: Rnd3, a small Rho GTPase, is involved in the regulation of cell actin cytoskeleton dynamics, cell migration, and proliferation. The biological function of Rnd3 in the heart remains unexplored. OBJECTIVE: To define the functional role of the Rnd3 gene in the animal heart and investigate th...

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Udgivet i:Circ Res
Main Authors: Yang, Xiangsheng, Wang, Tiannan, Lin, Xi, Yue, Xiaojing, Wang, Qiongling, Wang, Guoliang, Fu, Qin, Ai, Xun, Chiang, David Y., Miyake, Christina Y., Wehrens, Xander H.T., Chang, Jiang
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282622/
https://ncbi.nlm.nih.gov/pubmed/25348166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.116.304940
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