The effects of alcohol on the pharmacokinetics and pharmacodynamics of the selective mu-opioid receptor antagonist GSK1521498 in healthy subjects

The mu-opioid system has a key role in hedonic and motivational processes critical to substance addiction. However, existing mu-opioid antagonists have had limited success as anti-addiction treatments. GSK1521498 is a selective and potent mu-opioid antagonist being developed for the treatment of ove...

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Detalhes bibliográficos
Publicado no:J Clin Pharmacol
Main Authors: Ziauddeen, Hisham, Nathan, Pradeep J, Dodds, Chris, Maltby, Kay, Miller, Sam R, Waterworth, Dawn, Song, Kijoung, Warren, Liling, Hosking, Louise, Zucchetto, Mauro, Bush, Mark, Johnson, Lakshmi Vasist, Sarai, Bhopinder, Mogg, Karin, Bradley, Brendan P, Richards, Duncan B, Fletcher, Paul C, Bullmore, Edward T
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282435/
https://ncbi.nlm.nih.gov/pubmed/23934621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.110
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