Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype

The A118G single-nucleotide polymorphism (SNP rs1799971) in the μ-opioid receptor gene, OPRM1, has been much studied in relation to alcohol use disorders. The reported effects of allelic variation at this SNP on alcohol-related behaviors, and on opioid receptor antagonist treatments, have been incon...

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Vydáno v:Neuropsychopharmacology
Hlavní autoři: Ziauddeen, Hisham, Nestor, Liam J, Subramaniam, Naresh, Dodds, Chris, Nathan, Pradeep J, Miller, Sam R, Sarai, Bhopinder K, Maltby, Kay, Fernando, Disala, Warren, Liling, Hosking, Louise K, Waterworth, Dawn, Korzeniowska, Anna, Win, Beta, Richards, Duncan B, Vasist Johnson, Lakshmi, Fletcher, Paul C, Bullmore, Edward T
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026731/
https://ncbi.nlm.nih.gov/pubmed/27109624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2016.60
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