The effects of alcohol on the pharmacokinetics and pharmacodynamics of the selective mu-opioid receptor antagonist GSK1521498 in healthy subjects

The mu-opioid system has a key role in hedonic and motivational processes critical to substance addiction. However, existing mu-opioid antagonists have had limited success as anti-addiction treatments. GSK1521498 is a selective and potent mu-opioid antagonist being developed for the treatment of ove...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Clin Pharmacol
Päätekijät: Ziauddeen, Hisham, Nathan, Pradeep J, Dodds, Chris, Maltby, Kay, Miller, Sam R, Waterworth, Dawn, Song, Kijoung, Warren, Liling, Hosking, Louise, Zucchetto, Mauro, Bush, Mark, Johnson, Lakshmi Vasist, Sarai, Bhopinder, Mogg, Karin, Bradley, Brendan P, Richards, Duncan B, Fletcher, Paul C, Bullmore, Edward T
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BlackWell Publishing Ltd 2013
Aiheet:
Original Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282435/
https://ncbi.nlm.nih.gov/pubmed/23934621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.110
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