The effects of alcohol on the pharmacokinetics and pharmacodynamics of the selective mu-opioid receptor antagonist GSK1521498 in healthy subjects

The mu-opioid system has a key role in hedonic and motivational processes critical to substance addiction. However, existing mu-opioid antagonists have had limited success as anti-addiction treatments. GSK1521498 is a selective and potent mu-opioid antagonist being developed for the treatment of ove...

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Pubblicato in:J Clin Pharmacol
Autori principali: Ziauddeen, Hisham, Nathan, Pradeep J, Dodds, Chris, Maltby, Kay, Miller, Sam R, Waterworth, Dawn, Song, Kijoung, Warren, Liling, Hosking, Louise, Zucchetto, Mauro, Bush, Mark, Johnson, Lakshmi Vasist, Sarai, Bhopinder, Mogg, Karin, Bradley, Brendan P, Richards, Duncan B, Fletcher, Paul C, Bullmore, Edward T
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2013
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282435/
https://ncbi.nlm.nih.gov/pubmed/23934621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.110
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