Discovery and structural characterization of an allosteric inhibitor of bacterial cis-prenyltransferase

Undecaprenyl pyrophosphate synthase (UPPs) is an essential enzyme in a key bacterial cell wall synthesis pathway. It catalyzes the consecutive condensations of isopentenyl pyrophosphate (IPP) groups on to a trans-farnesyl pyrophosphate (FPP) to produce a C55 isoprenoid, undecaprenyl pyrophosphate (U...

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Bibliographic Details
Published in:Protein Sci
Main Authors: Danley, Dennis E, Baima, Eric T, Mansour, Mahmoud, Fennell, Kimberly F, Chrunyk, Boris A, Mueller, John P, Liu, Shenping, Qiu, Xiayang
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282408/
https://ncbi.nlm.nih.gov/pubmed/25287857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2579
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