Ligation of TLR7 by rheumatoid arthritis synovial fluid single strand RNA induces transcription of TNF-α in monocytes

OBJECTIVE: The aim of the study was to characterize the expression, regulation and pathogenic role of TLR7 and TLR8 in rheumatoid arthritis (RA). METHODS: Expression of TLR7 and TLR8 was demonstrated in RA, osteoarthritis (OA) and normal (NL) synovial tissues (ST) employing immunohistochemistry. We...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Chamberlain, Nathan D., Kim, Seung-jae, Vila, Olga M., Volin, Michael V., Volkov, Suncica, Pope, Richard M., Arami, Shiva, Mandelin, Arthur M., Shahrara, Shiva
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281889/
https://ncbi.nlm.nih.gov/pubmed/22730373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2011-201203
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