p53 Protein-mediated Regulation of Phosphoglycerate Dehydrogenase (PHGDH) Is Crucial for the Apoptotic Response upon Serine Starvation

Although p53 is frequently mutated in human cancers, about 80% of human melanomas retain wild-type p53. Here we report that PHGDH, the key metabolic enzyme that catalyzes the rate-limiting step of the serine biosynthesis pathway, is a target of p53 in human melanoma cells. p53 suppresses PHGDH expre...

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Publicado en:J Biol Chem
Autores principales: Ou, Yang, Wang, Shang-Jui, Jiang, Le, Zheng, Bin, Gu, Wei
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Gene Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281747/
https://ncbi.nlm.nih.gov/pubmed/25404730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.616359
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