Sequential Actions of SIRT1-RELB-SIRT3 Coordinate Nuclear-Mitochondrial Communication during Immunometabolic Adaptation to Acute Inflammation and Sepsis

We reported that NAD(+)-dependent SIRT1, RELB, and SIRT6 nuclear proteins in monocytes regulate a switch from the glycolysis-dependent acute inflammatory response to fatty acid oxidation-dependent sepsis adaptation. We also found that disrupting SIRT1 activity during adaptation restores immunometabo...

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Foilsithe in:J Biol Chem
Main Authors: Liu, Tie Fu, Vachharajani, Vidula, Millet, Patrick, Bharadwaj, Manish S., Molina, Anthony J., McCall, Charles E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2015
Ábhair:
Immunology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281742/
https://ncbi.nlm.nih.gov/pubmed/25404738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.566349
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