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MFN2 Couples Glutamate Excitotoxicity and Mitochondrial Dysfunction in Motor Neurons
Mitochondrial dysfunction plays a central role in glutamate-evoked neuronal excitotoxicity, and mitochondrial fission/fusion dynamics are essential for mitochondrial morphology and function. Here, we establish a novel mechanistic linker among glutamate excitotoxicity, mitochondrial dynamics, and mit...
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| 發表在: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4281719/ https://ncbi.nlm.nih.gov/pubmed/25416777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.617167 |
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