MFN2 Couples Glutamate Excitotoxicity and Mitochondrial Dysfunction in Motor Neurons

Mitochondrial dysfunction plays a central role in glutamate-evoked neuronal excitotoxicity, and mitochondrial fission/fusion dynamics are essential for mitochondrial morphology and function. Here, we establish a novel mechanistic linker among glutamate excitotoxicity, mitochondrial dynamics, and mit...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wang, Wenzhang, Zhang, Fan, Li, Li, Tang, Fangqiang, Siedlak, Sandra L., Fujioka, Hisashi, Liu, Yingchao, Su, Bo, Pi, Yan, Wang, Xinglong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281719/
https://ncbi.nlm.nih.gov/pubmed/25416777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.617167
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