Interleukin-1β Enhances FasL-Induced Caspase-3/-7 Activity without Increasing Apoptosis in Primary Mouse Hepatocytes

Sustained inflammation may increase the susceptibility of hepatocytes to apoptotic cell death and therefore exacerbate liver damage. Here we report that the pro-inflammatory cytokine IL-1β sensitizes primary murine hepatocytes to Fas ligand (FasL)-induced caspase-3/-7 activity. This process was depe...

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Veröffentlicht in:PLoS One
Hauptverfasser: Lutz, Anna, Sanwald, Julia, Thomas, Maria, Feuer, Ronny, Sawodny, Oliver, Ederer, Michael, Borner, Christoph, Humar, Matjaz, Merfort, Irmgard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281199/
https://ncbi.nlm.nih.gov/pubmed/25551609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115603
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