TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation

Although it is well established that TNFα contributes to hepatitis, liver failure and associated hepatocarcinogenesis via the regulation of inflammation, its pro-apoptotic role in the liver has remained enigmatic. On its own, TNFα is unable to trigger apoptosis. However, when combined with the trans...

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Udgivet i:Cell Death Dis
Main Authors: Faletti, Laura, Peintner, Lukas, Neumann, Simon, Sandler, Sandra, Grabinger, Thomas, Mac Nelly, Sabine, Merfort, Irmgard, Huang, Chun-Hao, Tschaharganeh, Darjus, Kang, Tae-Won, Heinzmann, Florian, D’Artista, Luana, Maurer, Ulrich, Brunner, Thomas, Lowe, Scott, Zender, Lars, Borner, Christoph
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125596/
https://ncbi.nlm.nih.gov/pubmed/30185788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0935-9
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