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Switch from type II to I Fas/CD95 death signaling upon in vitro culturing of primary hepatocytes
Fas/CD95-induced apoptosis of hepatocytes in vivo proceeds through the so-called type II pathway, requiring the pro-apoptotic BH3-only Bcl-2 family member Bid for mitochondrial death signaling. Consequently, Bid-deficient mice are protected from anti-Fas antibody injection induced fatal hepatitis. H...
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Main Authors: | , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2008
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2993691/ https://ncbi.nlm.nih.gov/pubmed/19003879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22541 |
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