Switch from type II to I Fas/CD95 death signaling upon in vitro culturing of primary hepatocytes

Fas/CD95-induced apoptosis of hepatocytes in vivo proceeds through the so-called type II pathway, requiring the pro-apoptotic BH3-only Bcl-2 family member Bid for mitochondrial death signaling. Consequently, Bid-deficient mice are protected from anti-Fas antibody injection induced fatal hepatitis. H...

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Main Authors: Walter, Dorothée, Schmich, Kathrin, Vogel, Sandra, Pick, Robert, Kaufmann, Thomas, Hochmuth, Florian Christoph, Haber, Angelika, Neubert, Karin, McNelly, Sabine, von Weizsäcker, Fritz, Merfort, Irmgard, Maurer, Ulrich, Strasser, Andreas, Borner, Christoph
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993691/
https://ncbi.nlm.nih.gov/pubmed/19003879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22541
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