Synthesis and Biological Evaluation of Pentacyclic Strychnos Alkaloids as Selective Modulators of the ABCC10 (MRP7) Efflux Pump

[Image: see text] The selective modulation of ATP-binding cassette (ABC) efflux pumps overexpressed in multidrug resistant cancers (MDR) and attendant resensitization to chemotherapeutic agents represent a promising strategy for treating cancer. We have synthesized four novel pentacyclic Strychnos a...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Teijaro, Christiana N., Munagala, Surendrachary, Zhao, Senzhi, Sirasani, Gopal, Kokkonda, Praveen, Malofeeva, Ekaterina V., Hopper-Borge, Elizabeth, Andrade, Rodrigo B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281106/
https://ncbi.nlm.nih.gov/pubmed/25419978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501189p
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