Intratracheal Instillation of High Dose Adenoviral Vectors Is Sufficient to Induce Lung Injury and Fibrosis in Mice

RATIONALE: Replication deficient adenoviruses (Ad) vectors are common tools in gene therapy. Since Ad vectors are known to activate innate and adaptive immunity, we investigated whether intratracheal administration of Ad vectors alone is sufficient to induce lung injury and pulmonary fibrosis. METHO...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhou, Qiyuan, Chen, Tianji, Bozkanat, Melike, Ibe, Joyce Christina F., Christman, John W., Raj, J. Usha, Zhou, Guofei
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281082/
https://ncbi.nlm.nih.gov/pubmed/25551570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116142
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