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Intratracheal Instillation of High Dose Adenoviral Vectors Is Sufficient to Induce Lung Injury and Fibrosis in Mice

RATIONALE: Replication deficient adenoviruses (Ad) vectors are common tools in gene therapy. Since Ad vectors are known to activate innate and adaptive immunity, we investigated whether intratracheal administration of Ad vectors alone is sufficient to induce lung injury and pulmonary fibrosis. METHO...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Zhou, Qiyuan, Chen, Tianji, Bozkanat, Melike, Ibe, Joyce Christina F., Christman, John W., Raj, J. Usha, Zhou, Guofei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281082/
https://ncbi.nlm.nih.gov/pubmed/25551570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116142
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