Intratracheal Instillation of High Dose Adenoviral Vectors Is Sufficient to Induce Lung Injury and Fibrosis in Mice

RATIONALE: Replication deficient adenoviruses (Ad) vectors are common tools in gene therapy. Since Ad vectors are known to activate innate and adaptive immunity, we investigated whether intratracheal administration of Ad vectors alone is sufficient to induce lung injury and pulmonary fibrosis. METHO...

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Vydáno v:PLoS One
Hlavní autoři: Zhou, Qiyuan, Chen, Tianji, Bozkanat, Melike, Ibe, Joyce Christina F., Christman, John W., Raj, J. Usha, Zhou, Guofei
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281082/
https://ncbi.nlm.nih.gov/pubmed/25551570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116142
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