Mice lacking epidermal PPARγ exhibit a marked augmentation in photocarcinogenesis associated with increased UVB-induced apoptosis, inflammation and barrier dysfunction

Recent studies suggest that peroxisome proliferator-activated receptor gamma (PPARγ) agonists may have cancer chemopreventive activity. Other studies have shown that loss of epidermal PPARγ results in enhanced chemical carcinogenesis in mice via unknown mechanisms. However, ultraviolet B (UVB) expos...

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Detalhes bibliográficos
Publicado no:Int J Cancer
Main Authors: Sahu, Ravi P., DaSilva, Sonia C., Rashid, Badri, Martel, Kellie Clay, Jernigan, Danielle, Mehta, Shama R., Mohamed, Deena R., Rezania, Samin, Bradish, Joshua R., Armstrong, Andrew B., Warren, Simon, Konger, Raymond L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280796/
https://ncbi.nlm.nih.gov/pubmed/22467332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27562
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