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G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments

Angiogenin (ANG) is a stress-activated ribonuclease that promotes the survival of motor neurons. Ribonuclease inactivating point mutations are found in a subset of patients with ALS, a fatal neurodegenerative disease with no cure. We recently showed that ANG cleaves tRNA within anticodon loops to pr...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ivanov, Pavel, O’Day, Elizabeth, Emara, Mohamed M., Wagner, Gerhard, Lieberman, Judy, Anderson, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280610/
https://ncbi.nlm.nih.gov/pubmed/25404306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407361111
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