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Targeting acidity in diseased tissues: mechanism and applications of the membrane-inserting peptide, pHLIP
pHLIPs are a family of soluble ~36 amino acid peptides, which bind to membrane surfaces. If the environment is acidic, a pHLIP folds and inserts across the membrane to form a stable transmembrane helix, thus preferentially locating itself in acidic tissues. Since tumors and other disease tissues are...
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| Опубликовано в: : | Arch Biochem Biophys |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4280328/ https://ncbi.nlm.nih.gov/pubmed/25444855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2014.11.002 |
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