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Pharmacologic Targeting of Sphingosine-1-Phosphate Receptor 1 Improves the Renal Microcirculation during Sepsis in the Mouse
Microvascular failure is hallmark of sepsis in humans and is recognized as a strong predictor of mortality. In the mouse subjected to cecal ligation and puncture (CLP) to induce a clinically relevant sepsis, renal microvascular permeability increases and peritubular capillary perfusion declines rapi...
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| Gepubliceerd in: | J Pharmacol Exp Ther |
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| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4279105/ https://ncbi.nlm.nih.gov/pubmed/25355645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.219394 |
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