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Rolipram Improves Renal Perfusion and Function during Sepsis in the Mouse

Microcirculatory dysfunction is correlated with increased mortality among septic patients and is believed to be a major contributor to the development of acute kidney injury (AKI). Rolipram, a selective phosphodiesterase 4 (PDE4) inhibitor, has been shown to reduce microvascular permeability and in...

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Bibliografski detalji
Glavni autori: Holthoff, Joseph H., Wang, Zhen, Patil, Naeem K., Gokden, Neriman, Mayeux, Philip R.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807062/
https://ncbi.nlm.nih.gov/pubmed/24018639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.208520
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