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What Can Crystal Structures of Aminergic Receptors Tell Us about Designing Subtype-Selective Ligands?
G protein–coupled receptors (GPCRs) are integral membrane proteins that represent an important class of drug targets. In particular, aminergic GPCRs interact with a significant portion of drugs currently on the market. However, most drugs that target these receptors are associated with undesirable s...
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| Publicado en: | Pharmacol Rev |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4279073/ https://ncbi.nlm.nih.gov/pubmed/25527701 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/pr.114.009944 |
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