What Can Crystal Structures of Aminergic Receptors Tell Us about Designing Subtype-Selective Ligands?

G protein–coupled receptors (GPCRs) are integral membrane proteins that represent an important class of drug targets. In particular, aminergic GPCRs interact with a significant portion of drugs currently on the market. However, most drugs that target these receptors are associated with undesirable s...

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Bibliographic Details
Published in:Pharmacol Rev
Main Authors: Michino, Mayako, Beuming, Thijs, Donthamsetti, Prashant, Newman, Amy Hauck, Javitch, Jonathan A., Shi, Lei
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2015
Subjects:
Review Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279073/
https://ncbi.nlm.nih.gov/pubmed/25527701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/pr.114.009944
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