Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukaemic compound PEP005 in primary AML cells

We showed previously that PEP005 induced apoptosis in leukaemic cell lines and blasts from patients with acute myeloid leukaemia (AML). Here we assess the anti-leukeamic effects of PEP005 in vivo and determine the mechanism of resistance of PEP005 non-responsive cells. We used 2 human xenograft mous...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncoscience
Prif Awduron: Hampson, Peter, Wang, Keqing, Ersvær, Elisabeth, McCormack, Emmet, Schüler, Julia, Fiebig, Heinz-Herbert, Gjertsen, Bjørn Tore, Bruserud, Øystein, Lord, Janet M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2014
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278328/
https://ncbi.nlm.nih.gov/pubmed/25594060
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