The Protein Kinase C Agonist PEP005 (Ingenol 3-Angelate) in the Treatment of Human Cancer: A Balance between Efficacy and Toxicity

The diterpene ester ingenol-3-angelate (referred to as PEP005) is derived from the plant Euphorbia peplus. Crude euphorbia extract causes local toxicity and transient inflammation when applied topically and has been used in the treatment of warts, skin keratoses and skin cancer. PEP005 is a broad ra...

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Bibliografiske detaljer
Main Authors: Ersvaer, Elisabeth, Kittang, Astrid Olsnes, Hampson, Peter, Sand, Kristoffer, Gjertsen, Bjørn Tore, Lord, Janet M., Bruserud, Øystein
Format: Artigo
Sprog:Inglês
Udgivet: Molecular Diversity Preservation International 2010
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206618/
https://ncbi.nlm.nih.gov/pubmed/22069553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins2010174
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