The Protein Kinase C Agonist PEP005 (Ingenol 3-Angelate) in the Treatment of Human Cancer: A Balance between Efficacy and Toxicity

The diterpene ester ingenol-3-angelate (referred to as PEP005) is derived from the plant Euphorbia peplus. Crude euphorbia extract causes local toxicity and transient inflammation when applied topically and has been used in the treatment of warts, skin keratoses and skin cancer. PEP005 is a broad ra...

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Autors principals: Ersvaer, Elisabeth, Kittang, Astrid Olsnes, Hampson, Peter, Sand, Kristoffer, Gjertsen, Bjørn Tore, Lord, Janet M., Bruserud, Øystein
Format: Artigo
Idioma:Inglês
Publicat: Molecular Diversity Preservation International 2010
Matèries:
Review
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206618/
https://ncbi.nlm.nih.gov/pubmed/22069553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins2010174
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