The Protein Kinase C Agonist PEP005 (Ingenol 3-Angelate) in the Treatment of Human Cancer: A Balance between Efficacy and Toxicity

The diterpene ester ingenol-3-angelate (referred to as PEP005) is derived from the plant Euphorbia peplus. Crude euphorbia extract causes local toxicity and transient inflammation when applied topically and has been used in the treatment of warts, skin keratoses and skin cancer. PEP005 is a broad ra...

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Библиографические подробности
Главные авторы: Ersvaer, Elisabeth, Kittang, Astrid Olsnes, Hampson, Peter, Sand, Kristoffer, Gjertsen, Bjørn Tore, Lord, Janet M., Bruserud, Øystein
Формат: Artigo
Язык:Inglês
Опубликовано: Molecular Diversity Preservation International 2010
Предметы:
Review
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206618/
https://ncbi.nlm.nih.gov/pubmed/22069553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins2010174
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