Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukaemic compound PEP005 in primary AML cells

We showed previously that PEP005 induced apoptosis in leukaemic cell lines and blasts from patients with acute myeloid leukaemia (AML). Here we assess the anti-leukeamic effects of PEP005 in vivo and determine the mechanism of resistance of PEP005 non-responsive cells. We used 2 human xenograft mous...

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發表在:Oncoscience
Main Authors: Hampson, Peter, Wang, Keqing, Ersvær, Elisabeth, McCormack, Emmet, Schüler, Julia, Fiebig, Heinz-Herbert, Gjertsen, Bjørn Tore, Bruserud, Øystein, Lord, Janet M.
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2014
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278328/
https://ncbi.nlm.nih.gov/pubmed/25594060
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