The HDACi Panobinostat Shows Growth Inhibition Both In Vitro and in a Bioluminescent Orthotopic Surgical Xenograft Model of Ovarian Cancer

BACKGROUND: In most epithelial ovarian carcinomas (EOC), epigenetic changes are evident, and overexpression of histone deacetylases (HDACs) represents an important manifestation. In this study, we wanted to evaluate the effects of the novel HDAC inhibitor (HDACi) panobinostat, both alone and in comb...

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Detalhes bibliográficos
Publicado no:PLoS One
Principais autores: Helland, Øystein, Popa, Mihaela, Bischof, Katharina, Gjertsen, Bjørn Tore, McCormack, Emmet, Bjørge, Line
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924861/
https://ncbi.nlm.nih.gov/pubmed/27352023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158208
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