Chronic Continuous Exenatide Infusion Does Not Cause Pancreatic Inflammation and Ductal Hyperplasia in Non-Human Primates

In this study, we aimed to evaluate the effects of exenatide (EXE) treatment on exocrine pancreas of nonhuman primates. To this end, 52 baboons (Papio hamadryas) underwent partial pancreatectomy, followed by continuous infusion of EXE or saline (SAL) for 14 weeks. Histological analysis, immunohistoc...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Fiorentino, Teresa Vanessa, Owston, Michael, Abrahamian, Gregory, La Rosa, Stefano, Marando, Alessandro, Perego, Carla, Di Cairano, Eliana S., Finzi, Giovanna, Capella, Carlo, Sessa, Fausto, Casiraghi, Francesca, Paez, Ana, Adivi, Ashwin, Davalli, Alberto, Fiorina, Paolo, Guardado Mendoza, Rodolfo, Comuzzie, Anthony G., Sharp, Mark, DeFronzo, Ralph A., Halff, Glenn, Dick, Edward J., Folli, Franco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2015
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278248/
https://ncbi.nlm.nih.gov/pubmed/25447052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.09.009
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