Pancreatic islet amyloidosis, β-cell apoptosis, and α-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons

β-Cell dysfunction is an important factor in the development of hyperglycemia of type-2 diabetes mellitus, and pancreatic islet amyloidosis (IA) has been postulated to be one of the main contributors to impaired insulin secretion. The aim of this study was to evaluate the correlation of IA with meta...

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主要な著者: Guardado-Mendoza, Rodolfo, Davalli, Alberto M., Chavez, Alberto O., Hubbard, Gene B., Dick, Edward J., Majluf-Cruz, Abraham, Tene-Perez, Carlos E., Goldschmidt, Lukasz, Hart, John, Perego, Carla, Comuzzie, Anthony G., Tejero, Maria Elizabeth, Finzi, Giovanna, Placidi, Claudia, La Rosa, Stefano, Capella, Carlo, Halff, Glenn, Gastaldelli, Amalia, DeFronzo, Ralph A., Folli, Franco
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2009
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729008/
https://ncbi.nlm.nih.gov/pubmed/19666551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906471106
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