Pancreatic islet amyloidosis, β-cell apoptosis, and α-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons

β-Cell dysfunction is an important factor in the development of hyperglycemia of type-2 diabetes mellitus, and pancreatic islet amyloidosis (IA) has been postulated to be one of the main contributors to impaired insulin secretion. The aim of this study was to evaluate the correlation of IA with meta...

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Autors principals: Guardado-Mendoza, Rodolfo, Davalli, Alberto M., Chavez, Alberto O., Hubbard, Gene B., Dick, Edward J., Majluf-Cruz, Abraham, Tene-Perez, Carlos E., Goldschmidt, Lukasz, Hart, John, Perego, Carla, Comuzzie, Anthony G., Tejero, Maria Elizabeth, Finzi, Giovanna, Placidi, Claudia, La Rosa, Stefano, Capella, Carlo, Halff, Glenn, Gastaldelli, Amalia, DeFronzo, Ralph A., Folli, Franco
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729008/
https://ncbi.nlm.nih.gov/pubmed/19666551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906471106
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