Pancreatic islet amyloidosis, β-cell apoptosis, and α-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons

β-Cell dysfunction is an important factor in the development of hyperglycemia of type-2 diabetes mellitus, and pancreatic islet amyloidosis (IA) has been postulated to be one of the main contributors to impaired insulin secretion. The aim of this study was to evaluate the correlation of IA with meta...

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Bibliographic Details
Main Authors: Guardado-Mendoza, Rodolfo, Davalli, Alberto M., Chavez, Alberto O., Hubbard, Gene B., Dick, Edward J., Majluf-Cruz, Abraham, Tene-Perez, Carlos E., Goldschmidt, Lukasz, Hart, John, Perego, Carla, Comuzzie, Anthony G., Tejero, Maria Elizabeth, Finzi, Giovanna, Placidi, Claudia, La Rosa, Stefano, Capella, Carlo, Halff, Glenn, Gastaldelli, Amalia, DeFronzo, Ralph A., Folli, Franco
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729008/
https://ncbi.nlm.nih.gov/pubmed/19666551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906471106
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