Role of the Urokinase-Fibrinolytic System in Epithelial–Mesenchymal Transition during Lung Injury

Alveolar type II epithelial (ATII) cell injury precedes development of pulmonary fibrosis. Mice lacking urokinase-type plasminogen activator (uPA) are highly susceptible, whereas those deficient in plasminogen activator inhibitor (PAI-1) are resistant to lung injury and pulmonary fibrosis. Epithelia...

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Bibliographic Details
Published in:Am J Pathol
Main Authors: Marudamuthu, Amarnath Satheesh, Bhandary, Yashodhar Prabhakar, Shetty, Shwetha Kumari, Fu, Jian, Sathish, Venkatachalem, Prakash, YS, Shetty, Sreerama
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2015
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Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278237/
https://ncbi.nlm.nih.gov/pubmed/25447049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.08.027
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