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Targeted Deletion of PTEN in Cardiomyocytes Renders Cardiac Contractile Dysfunction through Interruption of Pink1-AMPK Signaling and Autophagy
Phosphatase and tensin homolog deleted from chromosome 10 (PTEN) has been implicated in the maintenance of cardiac homeostasis although the underlying mechanism(s) remains elusive. We generated a murine model of cardiomyocyte-specific knockout of PTEN to evaluate cardiac geometry and contractile fun...
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| Publicado no: | Biochim Biophys Acta |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4277923/ https://ncbi.nlm.nih.gov/pubmed/25229693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2014.09.002 |
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