Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B.

Documenti analoghi

• Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.
  di: Traenckner, E B, et al.
  Pubblicazione: (1995)
• Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.
  di: Brown, K, et al.
  Pubblicazione: (1993)
• Control of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alpha.
  di: Hay, R T, et al.
  Pubblicazione: (1999)
• Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B.
  di: DiDonato, J A, et al.
  Pubblicazione: (1995)
• In vivo stimulation of I kappa B phosphorylation is not sufficient to activate NF-kappa B.
  di: Alkalay, I, et al.
  Pubblicazione: (1995)