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Control of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alpha.

In unstimulated cells the transcription factor NF-kappa B is held in the cytoplasm in an inactive state by I kappa B inhibitor proteins. Ultimately activation of NF-kappa B is achieved by ubiquitination and proteasome-mediated degradation of I kappa B alpha and we have therefore investigated factors...

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Bibliografiske detaljer
Main Authors: Hay, R T, Vuillard, L, Desterro, J M, Rodriguez, M S
Format: Artigo
Sprog:Inglês
Udgivet: 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1692667/
https://ncbi.nlm.nih.gov/pubmed/10582246
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