Inducible nuclear expression of newly synthesized I kappa B alpha negatively regulates DNA-binding and transcriptional activities of NF-kappa B.

Míreanna Comhchosúla

• Inducible degradation of I kappa B alpha in vitro and in vivo requires the acidic C-terminal domain of the protein.
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• Control of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alpha.
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• Role of unphosphorylated, newly synthesized I kappa B beta in persistent activation of NF-kappa B.
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• Domain organization of I kappa B alpha and sites of interaction with NF-kappa B p65.
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• Permanent occupancy of the human immunodeficiency virus type 1 enhancer by NF-kappa B is needed for persistent viral replication in monocytes.
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  Foilsithe: (1996)