Epigenetic reprogramming of HOXC10 in endocrine-resistant breast cancer

Resistance to aromatase inhibitors (AIs) is a major clinical problem in the treatment of estrogen receptor positive breast cancer. In two breast cancer cell line models of AI resistance we identified widespread DNA hyper- and hypomethylation, with enrichment for promoter hypermethylation of developm...

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Bibliografiset tiedot
Julkaisussa:Sci Transl Med
Päätekijät: Pathiraja, Thushangi N., Nayak, Shweta, Xi, Yuanxin, Jiang, Shiming, Garee, Jason P., Edwards, Dean P., Lee, Adrian V., Chen, Jian, Shea, Martin J., Santen, Richard J., Gannon, Frank, Kangaspeska, Sara, Jelinek, Jaroslav, Issa, Jean-Pierre J., Richer, Jennifer K., Elias, Anthony, McIlroy, Marie, Young, Leonie, Davidson, Nancy E., Schiff, Rachel, Li, Wei, Oesterreich, Steffi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277862/
https://ncbi.nlm.nih.gov/pubmed/24670685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3008326
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