Prenatal Metformin Exposure in a Maternal High Fat Diet Mouse Model Alters the Transcriptome and Modifies the Metabolic Responses of the Offspring

AIMS: Despite the wide use of metformin in metabolically challenged pregnancies, the long-term effects on the metabolism of the offspring are not known. We studied the long-term effects of prenatal metformin exposure during metabolically challenged pregnancy in mice. MATERIALS AND METHODS: Female mi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Salomäki, Henriikka, Heinäniemi, Merja, Vähätalo, Laura H., Ailanen, Liisa, Eerola, Kim, Ruohonen, Suvi T., Pesonen, Ullamari, Koulu, Markku
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277397/
https://ncbi.nlm.nih.gov/pubmed/25541979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115778
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