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Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions
BACKGROUND AND PURPOSE: The objective of this study was to determine how the AMPK activating antidiabetic drug metformin affects the major activator of hepatic gluconeogenesis, PPARγ coactivator 1α (PGC-1α) and liver functions regulated by PGC-1α. EXPERIMENTAL APPROACH: Mouse and human primary hepat...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BlackWell Publishing Ltd
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3997275/ https://ncbi.nlm.nih.gov/pubmed/24428821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12585 |
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