Unfolded Protein Response-regulated Drosophila Fic (dFic) Protein Reversibly AMPylates BiP Chaperone during Endoplasmic Reticulum Homeostasis

Drosophila Fic (dFic) mediates AMPylation, a covalent attachment of adenosine monophosphate (AMP) from ATP to hydroxyl side chains of protein substrates. Here, we identified the endoplasmic reticulum (ER) chaperone BiP as a substrate for dFic and mapped the modification site to Thr-366 within the AT...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Ham, Hyeilin, Woolery, Andrew R., Tracy, Charles, Stenesen, Drew, Krämer, Helmut, Orth, Kim
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276871/
https://ncbi.nlm.nih.gov/pubmed/25395623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.612515
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