Chargement en cours...
Adaptor Protein GRB2 Promotes Src Tyrosine Kinase Activation and Podosomal Organization by Protein-tyrosine Phosphatase ϵ in Osteoclasts
The non-receptor isoform of protein-tyrosine phosphatase ϵ (cyt-PTPe) supports adhesion of bone-resorbing osteoclasts by activating Src downstream of integrins. Loss of cyt-PTPe reduces Src activity in osteoclasts, reduces resorption of mineralized matrix both in vivo and in cell culture, and induce...
Enregistré dans:
| Publié dans: | J Biol Chem |
|---|---|
| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2014
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4276870/ https://ncbi.nlm.nih.gov/pubmed/25381250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.603548 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|