Adaptor Protein GRB2 Promotes Src Tyrosine Kinase Activation and Podosomal Organization by Protein-tyrosine Phosphatase ϵ in Osteoclasts

The non-receptor isoform of protein-tyrosine phosphatase ϵ (cyt-PTPe) supports adhesion of bone-resorbing osteoclasts by activating Src downstream of integrins. Loss of cyt-PTPe reduces Src activity in osteoclasts, reduces resorption of mineralized matrix both in vivo and in cell culture, and induce...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Levy-Apter, Einat, Finkelshtein, Eynat, Vemulapalli, Vidyasiri, Li, Shawn S.-C., Bedford, Mark T., Elson, Ari
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276870/
https://ncbi.nlm.nih.gov/pubmed/25381250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.603548
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